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Doxycycline, doxycycline monohydrate and doxycycline hyclate are yellow, crystalline powders with a bitter taste. The latter smells faintly of ethanol , a 1% aqueous solution has a pH of 2–3, and the specific rotation is [ α ] D 25 {\displaystyle [\alpha ]_{D}^{25}} −110° cm 3 /dm·g in 0.01 N methanolic hydrochloric acid .
Tetracyclines are generally used in the treatment of infections of the urinary tract, respiratory tract, and the intestines and are also used in the treatment of chlamydia, especially in patients allergic to β-lactams and macrolides; however, their use for these indications is less popular than it once was due to widespread development of resistance in the causative organisms.
Heritage Pharmaceuticals Inc. is a manufacturer of generic pharmaceuticals based in Eatontown, New Jersey, United States, and established in 2006. The company was involved in a 2014 congressional inquiry about the rising price of doxycycline hyclate initiated by Elijah Cummings and Bernie Sanders.
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A hyclate (Latin: hyclas) is a pharmaceutical term for hydrochloride hemiethanolate hemihydrate [1] [2] (·HCl· 1 / 2 EtOH· 1 / 2 H 2 O), e.g. doxycycline hyclate. [ 3 ] [ 4 ] References
It is used as a precursor in the industrial synthesis of doxycycline hyclate. [citation needed] It has been found to act as an agonist of the human pregnane X receptor ligand-binding domain and to induce CYP3A4 expression in vitro. [1]
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