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In this situation it is generally uncommon to talk about half-life in the first place, but sometimes people will describe the decay in terms of its "first half-life", "second half-life", etc., where the first half-life is defined as the time required for decay from the initial value to 50%, the second half-life is from 50% to 25%, and so on.
An effective half-life of the drug will involve a decay constant that represents the sum of the biological and physical decay constants, as in the formula: = + With the decay constant it is possible to calculate the effective half-life using the formula:
Absorption half-life 1 h, elimination half-life 12 h. Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma.
The biological half-lives "alpha half-life" and "beta half-life" of a substance measure how quickly a substance is distributed and eliminated. Physical optics: The intensity of electromagnetic radiation such as light or X-rays or gamma rays in an absorbent medium, follows an exponential decrease with distance into the absorbing medium.
The above equation makes clear the relationship between mass removal and clearance. It states that (with a constant mass generation) the concentration and clearance vary inversely with one another. If applied to creatinine (i.e. creatinine clearance ), it follows from the equation that if the serum creatinine doubles the clearance halves and ...
The half-life of this isotope is 6.480 days, [2] which corresponds to a total decay constant of 0.1070 d −1. Then the partial decay constants, as computed from the branching fractions, are 0.1050 d −1 for ε/β + decays, and 2.14×10 −4 d −1 for β − decays. Their respective partial half-lives are 6.603 d and 347 d.
The K a is related to the absorption half-life (t 1/2a) per the following equation: K a = ln(2) / t 1/2a. [1] K a values can typically only be found in research articles. [2] This is in contrast to parameters like bioavailability and elimination half-life, which can often be found in drug and pharmacology handbooks. [2]
Specific activity (symbol a) is the activity per unit mass of a radionuclide and is a physical property of that radionuclide. [1] [2] It is usually given in units of becquerel per kilogram (Bq/kg), but another commonly used unit of specific activity is the curie per gram (Ci/g).