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The difference with plasma donation is that the blood goes through a machine that collects only the plasma and sends the red and white blood cells and platelets back to the donor in a saline solution.
Donating plasma is similar in many ways to whole blood donation, though the end product is used for different purposes. Most plasmapheresis is for fractionation into other products; other blood donations are transfused with relatively minor modifications. Plasma that is collected solely for further manufacturing is called Source Plasma.
When donating whole blood or packed red blood cell (PRBC) transfusions, O-is the most desirable and is considered a "universal donor," since it has neither A nor B antigens and can be safely transfused to most recipients. Type AB+ is the "universal recipient" type for PRBC donations. However, for plasma the situation is somewhat reversed.
The blood donor center is the facility that collects blood components from screened blood donors, either whole blood or separate components such as plasma or platelets only via apheresis. These blood components are then transported to a central location for processing such as fractionation, testing and redistribution.
Usually the component returned is the red blood cells, the portion of the blood that takes the longest to replace. Using this method an individual can donate plasma or platelets much more frequently than they can safely donate whole blood. [76] These can be combined, with a donor giving both plasma and platelets in the same donation. [citation ...
You can donate as often as twice per week with at least two days in between donations at most private donation centers. This is possible because blood plasma regenerates every 24-48 hours.
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