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Mammalian cochlear hair cells are of two anatomically and functionally distinct types, known as outer, and inner hair cells. Damage to these hair cells results in decreased hearing sensitivity, and because the inner ear hair cells cannot regenerate, this damage is permanent. [4]
Stereocilia (along with the entirety of the hair cell) in mammals can be damaged or destroyed by excessive loud noises, disease, medications, as well as toxins and are not regenerable. [ 3 ] [ 11 ] Environmental noise induced hearing impairment is probably the most prevalent noise health effect according to the U.S. Environmental Protection ...
Once outer hair cells are damaged, they do not regenerate, and the result is a loss of sensitivity and an abnormally large growth of loudness (known as recruitment) in the part of the spectrum that the damaged cells serve. [13] While hearing loss has always been considered irreversible in mammals, fish and birds routinely repair such damage. A ...
A number of ototoxic medications can damage your ear structures by disrupting the delicate chemical balance of your inner ear or killing hair cells responsible for hearing, says Palmer.
Because mammals have very limited hair cell regeneration, hearing loss is essentially irreversible and therefore a therapeutic target for regeneration. [8] [2] There are also genetic diseases that can cause hair cell death such as Osteogenesis Imperfecta. [9] Cartoon representation of healthy vs damaged hair cells
For one, the tall hair cell is very similar in function to that of the inner hair cell, and the short hair cell, lacking afferent auditory-nerve fiber innervation, resembles the outer hair cell. One unavoidable difference, however, is that while all hair cells are attached to a tectorial membrane in birds, only the outer hair cells are attached ...
OAEs are a measurement of the activity of outer hair cells in the cochlea, and noise-induced hearing loss occurs as a result of damage to the outer hair cells in the cochlea. [12] [13] Therefore, the damage or loss of some outer hair cells will likely show up on OAEs before showing up on the audiogram. [12]
Structural damage to hair cells (primarily the outer hair cells) will result in hearing loss that can be characterized by an attenuation and distortion of incoming auditory stimuli. During hair cell death 'scars' develop, which prevent potassium rich fluid of the endolymph from mixing with the fluid on the basal domain. [86]