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Fundic gland polyposis is a medical syndrome where the fundus and the body of the stomach develop many fundic gland polyps.The condition has been described both in patients with familial adenomatous polyposis (FAP) and attenuated variants (AFAP), and in patients in whom it occurs sporadically.
A fundic gland polyp is a type of polyp, found in the fundus of the stomach. Fundic gland polyps are found in 0.8 to 1.9% of patients who undergo esophagogastroduodenoscopy, and are more common in middle-aged women. [2] The risk of malignancy is very low or none, when sporadic. [3]
Fundic gland polyposis is a medical syndrome where the fundus and the body of the stomach develop many fundic gland polyps. Pernicious anemia is caused when damaged parietal cells fail to produce the intrinsic factor necessary for the absorption of vitamin B12. This is the most common cause of vitamin B12 deficiency.
Hyperplastic polyp of the stomach Stomach: Elongated, tortuous, and cystic foveolae separated by edematous and inflamed stroma. [4] Gastric hyperplastic polyposis Fundic gland polyp: Fundus of stomach: Cystically dilated glands lined by chief cells, parietal cells and mucinous foveolar cells. [5] Very low or none, when sporadic. [6] Fundic ...
Immunofluorescence staining pattern of gastric parietal antibodies on a stomach section Parietal cells are part of fundic gland polyps (here shown in high magnification). [9] Peptic ulcers can result from over-acidity in the stomach. Antacids can be used to enhance the natural tolerance of the gastric lining.
0.6-cm polyp from the gastric body of a 46-year-old woman with possible gastroesophageal reflux. The otherwise normal mucosa is thrown up into a nodule by markedly dilated foveolar glands. Pathological and histological images courtesy of Ed Uthman at flickr. Date: 20 February 2009, 12:39: Source: Fundic Gland Polyp, Stomach. Uploaded by CFCF ...
Chief cells are part of fundic gland polyps (here shown in high magnification). [11]In gastric tissue, a loss of parietal cells due to chronic inflammation has been shown to affect chief cell differentiation and can induce chief cells to transdifferentiate back into neck cells and can lead to the formation of mucus cell metaplasia known as spasmolytic polypeptide expressing metaplasia (SPEM ...
The glands contains a number of cells, with the function of the glands changing depending on their position within the stomach. [citation needed] Within the body and fundus of the stomach lie the fundic glands. In general, these glands are lined by column-shaped cells that secrete a protective layer of mucus and bicarbonate.