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  2. CTCF - Wikipedia

    en.wikipedia.org/wiki/CTCF

    In recent studies, CTCF binding loss is reported to increase localized CpG methylation, which reflected another epigenetic remodeling role of CTCF in human genome. [26] [27] [28] CTCF binds to an average of about 55,000 DNA sites in 19 diverse cell types (12 normal and 7 immortal) and in total 77,811 distinct binding sites across all 19 cell ...

  3. Biochemical switches in the cell cycle - Wikipedia

    en.wikipedia.org/wiki/Biochemical_switches_in...

    The phases include the G1 and G2 phases, DNA replication or S phase, and the actual process of cell division, mitosis or M phase. [1] During the M phase, the chromosomes separate and cytokinesis occurs. The switches maintain the orderly progression of the cell cycle and act as checkpoints to ensure that each phase has been properly completed ...

  4. G2-M DNA damage checkpoint - Wikipedia

    en.wikipedia.org/wiki/G2-M_DNA_damage_checkpoint

    Steps of the cell cycle. The G 2-M checkpoint occurs between the G 2 and M phases. G2-M arrest. The G 2-M DNA damage checkpoint is an important cell cycle checkpoint in eukaryotic organisms that ensures that cells don't initiate mitosis until damaged or incompletely replicated DNA is sufficiently repaired.

  5. Cell cycle - Wikipedia

    en.wikipedia.org/wiki/Cell_cycle

    The eukaryotic cell cycle consists of four distinct phases: G 1 phase, S phase (synthesis), G 2 phase (collectively known as interphase) and M phase (mitosis and cytokinesis). M phase is itself composed of two tightly coupled processes: mitosis, in which the cell's nucleus divides, and cytokinesis, in which the cell's cytoplasm and cell membrane divides forming two daughter cells.

  6. Cell cycle checkpoint - Wikipedia

    en.wikipedia.org/wiki/Cell_cycle_checkpoint

    Similar to S Phase, G2 experiences a DNA damage checkpoint. The cell is once more examined for sites of DNA damage or incomplete replication, and the kinases ATR and ATM are recruited to damage sites. Activation of Chk1 and Chk2 also transpire, as well as p53 activation, to induce cell cycle arrest and halt progression into mitosis.

  7. Cell division - Wikipedia

    en.wikipedia.org/wiki/Cell_division

    Interphase consists of three main phases: G 1, S, and G 2. G 1 is a time of growth for the cell where specialized cellular functions occur in order to prepare the cell for DNA replication. [16] There are checkpoints during interphase that allow the cell to either advance or halt further development.

  8. Replication timing - Wikipedia

    en.wikipedia.org/wiki/Replication_timing

    Figure 1: Schematic of the cell cycle. outer ring: I = Interphase, M = Mitosis; inner ring: M = Mitosis, G 1 = Gap 1, G 2 = Gap 2, S = Synthesis; not in ring: G 0 = Gap 0/Resting. Replication timing refers to the order in which segments of DNA along the length of a chromosome are duplicated.

  9. Interphase - Wikipedia

    en.wikipedia.org/wiki/Interphase

    Interphase is the phase of the cell cycle in which a typical cell spends most of its life. Interphase is the "daily living" or metabolic phase of the cell, in which the cell obtains nutrients and metabolizes them, grows, replicates its DNA in preparation for mitosis, and conducts other "normal" cell functions. [1]

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