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Hemochromatosis type 4 is a hereditary iron overload disorder that affects ferroportin, an iron transport protein needed to export iron from cells into circulation. [1] Although the disease is rare, it is found throughout the world and affects people from various ethnic groups.
There are five types of hereditary hemochromatosis: type 1, 2 (2A, 2B), 3, 4 [9] and 5, [10] all caused by mutated genes. Hereditary hemochromatosis type 1 is the most frequent, and uniquely related to the HFE gene. It is most common among those of Northern European ancestry, in particular those of Celtic descent. [11]
Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
With 150 locations throughout the Cleveland metropolitan area, the University Hospitals health system encompasses hospitals, outpatient centers, and primary care clinics. University Hospitals Cleveland Medical Center is the main teaching hospital of Case Western Reserve University. [2] [3] It also has an affiliation with the Northeast Ohio ...
Cleveland Clinic is an American nonprofit academic medical center based in Cleveland, Ohio. [2] Owned and operated by the Cleveland Clinic Foundation, an Ohio nonprofit corporation , Cleveland Clinic was founded in 1921 by a group of faculty and alumni from the Case Western Reserve University School of Medicine .
In 2014 the nationally ranked health system, Cleveland Clinic invested $100 million into Akron General Medical Center and became a minority owner of the hospital. Additionally, the deal allowed the Cleveland Clinic to take over the hospital after a year, and Cleveland Clinic was allowed to choose three board members on Akron Gen's board. [12]
Richmond Heights city, Ohio – Racial and ethnic composition Note: the US Census treats Hispanic/Latino as an ethnic category. This table excludes Latinos from the racial categories and assigns them to a separate category. Hispanics/Latinos may be of any race. Race / Ethnicity (NH = Non-Hispanic) Pop 2000 [14] Pop 2010 [15] Pop 2020 [16 ...
Bellaire–Puritas is a neighborhood on the West Side of Cleveland, Ohio, in the United States. Originally part of the Village of West Park , it was annexed by the city in 1923. Formerly known as Puritas–Longmead , the neighborhood takes its name from the two streets which form its northern boundary: Puritas Avenue and Bellaire Road.