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  2. Polysulfated glycosaminoglycan - Wikipedia

    en.wikipedia.org/wiki/Polysulfated_glycosaminoglycan

    Side effects from intra-articular administration can include joint pain, swelling, lameness, and, rarely, infection of the joint. Intramuscular injection can cause dose-dependent inflammation and bleeding, since PSGAG is an analogue of the anticoagulant heparin. [4] In dogs, this may manifest as bleeding from the nose or as bloody stools. [7]

  3. Cosequin - Wikipedia

    en.wikipedia.org/wiki/Cosequin

    Cosequin comes in formulas specific for cats, dogs and horses. [2] According to the manufacturer Cosequin may be useful for pets with osteoarthritis (OA), but the efficacy is disputed. [3] Glucosamine is used in equine medicine, but little evidence indicates that it has any value in the treatment of joint disease in horses. [4]

  4. Glucosamine - Wikipedia

    en.wikipedia.org/wiki/Glucosamine

    Glucosamine is naturally present in the shells of shellfish, animal bones, bone marrow, and fungi. [22] D-Glucosamine is made naturally in the form of glucosamine-6-phosphate, and is the biochemical precursor of all nitrogen-containing sugars. [23]

  5. Chondroitin sulfate - Wikipedia

    en.wikipedia.org/wiki/Chondroitin_sulfate

    Chemical structure of one unit in a chondroitin sulfate chain. Chondroitin-4-sulfate: R 1 = H; R 2 = SO 3 H; R 3 = H. Chondroitin-6-sulfate: R 1 = SO 3 H; R 2, R 3 = H.. Chondroitin sulfate is a sulfated glycosaminoglycan (GAG) [1] composed of a chain of alternating sugars (N-acetylgalactosamine and glucuronic acid).

  6. Clinical trials on glucosamine and chondroitin - Wikipedia

    en.wikipedia.org/wiki/Clinical_trials_on...

    The Long-term Evaluation of Glucosamine Sulfate (LEGS) study ran between 2007 and 2011, [61] to study whether glucosamine sulfate, chondroitin sulfate or a combination of both are effective treatments for chronic knee pain due to osteoarthritis. 502 patients (from 605 enrolled) were followed for two years. [62]

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