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Malignant schwannoma, [1] Neurofibrosarcoma, [1] and Neurosarcoma [1] Micrograph of malignant peripheral nerve sheath tumour with the typical herringbone pattern . H&E stain .
New and more precisely defined entities include malignant melanotic nerve sheath tumor (formerly known as melanotic schwannoma) and hybrid nerve sheath tumors. [4] [5] The majority of peripheral nerve tumors are benign tumors of the nerve sheath (usually schwannomas); on rare occasions, they are metastatic tumors or originate from the nerve cells.
The primary Schwann cell differentiation and neoplastic proliferations are characteristics of peripheral nerve sheath tumors. For instance, the Schwann cell, which is the major neoplastic cell component of neurofibroma, [7] is cytologically distinguished by the expression of S-100 protein and wavy nuclear outlines.
Malignant melanotic nerve sheath tumor (previously known as melanotic schwannoma) is a rare aggressive peripheral nerve sheath tumor that typically develops in conjunction with spinal or visceral autonomic nerves, consisting uniformly of Schwann cells displaying melanocytic differentiation.
Micrograph of a psammomatous melanotic schwannoma with a psammoma body, as may be seen in Carney complex. H&E stain. Psammoma bodies may be seen in: Endosalpingiosis [10] Psammomatous melanotic schwannoma; Melanocytic nevus [11]
Schwannoma: Factor VIII: Dabska-type hemangioendothelioma Angiosarcoma: Factor XIII: Cutaneous focal mucinosis: Factor XIIIa: Dermal dendritic cell: Dermatofibroma Epithelioid cell histiocytoma: Fite: Leprosy Nocardiosis [nb 1] Fontana–Masson: Cryptococcus neoformans: Cryptococcus: Giemsa: Mast cell: Mastocytosis Mucopolysaccharidoses: Gomori ...
The spotty skin pigmentation and lentigines occur most commonly on the face, especially on the lips, eyelids, conjunctiva and oral mucosa. [3] Cardiac myxomas may lead to embolic strokes and heart failure [4] and may present with fever, joint pain, shortness of breath, diastolic rumble and tumor plop.
Psammomatous melanotic schwannoma: Carney complex: Sclerotic fibroma: Cowden syndrome: Trichilemmoma: Cowden syndrome Bannayan–Riley–Ruvalcaba syndrome: Sebaceous adenoma: Muir–Torre syndrome: Sebaceous carcinoma: Muir–Torre syndrome: Syringofibroadenoma: Clouston syndrome Schöpf–Schulz–Passarge syndrome: Syringoma: Down syndrome ...