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A sessile serrated lesion (SSL) is a premalignant flat (or sessile) lesion of the colon, predominantly seen in the cecum and ascending colon. SSLs are thought to lead to colorectal cancer through the (alternate) serrated pathway. [1] [2] This differs from most colorectal cancer, which arises from mutations starting with inactivation of the APC ...
Sessile serrated adenoma seen under microscopy with H&E stain. Serrated polyposis syndrome often does not cause symptoms. The risk of colon cancer is between 25 and 40%. [8] Sessile serrated polyps, as seen during endoscopy or colonoscopy, are flat (rather than raised) and are easily overlooked.
Micrograph of a sessile serrated adenoma. H&E stain. Sessile serrated adenomas are characterized by (1) basal dilation of the crypts, (2) basal crypt serration, (3) crypts that run horizontal to the basement membrane (horizontal crypts), and (4) crypt branching. The most common of these features is basal dilation of the crypts.
An adenoma is a tumor of glandular tissue, that has not (yet) gained the properties of cancer. [citation needed] The common adenomas of the colon (colorectal adenoma) are the tubular, tubulovillous, villous, and sessile serrated (SSA). [18]
A sessile serrated adenoma or traditional serrated adenoma is suspected if there is either of the following: [4] Nuclear stratification; Loss of polarity; Dysplasia; A sessile serrated adenoma is suspected in case of any of the following: [4] Size ≥0.5 cm; Location in right colon; If both are present, it is almost always an SSA.
Traditional serrated adenoma is a premalignant type of polyp found in the colon, often in the distal colon (sigmoid, rectum). Traditional serrated adenomas are a type of serrated polyp, and may occur sporadically or as a part of serrated polyposis syndrome. Traditional serrated adenomas are relatively rare, accounting for less than 1% of all ...