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The findings show a decrease in mortality among people 60 years of age and older — including people over the age of 85 — who took statins. The study is published in Annals of Internal Medicine .
The small number of available trials do not support the use of statins as an adjunctive therapy or as a monotherapy in multiple sclerosis. [223] A modelling study in the UK funded by the NIHR found that people aged 70 and older who take statins live longer in good health than those who do not, regardless of whether they have cardiovascular disease.
Statins are more effective than other lipid-regulating drugs at lowering LDL-cholesterol concentration, but they are less effective than the fibrates in reducing triglyceride concentration. However, statins reduce cardiovascular disease events and total mortality irrespective of the initial cholesterol concentration.
The Scandinavian Simvastatin Survival Study (also known as the 4S study), was a multicentre, randomized, double-blind, placebo-controlled clinical trial, which provided the initial data that supported the use of the cholesterol-lowering drug, simvastatin, in people with a moderately raised cholesterol and coronary heart disease (CHD); that is people who had previously had a heart attack or angina.
Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]
The trial focused on patients with normal low-density lipoprotein (LDL) cholesterol levels but increased levels of high-sensitivity C-reactive protein (hs-CRP). JUPITER was the first clinical trial to indicate that statin therapy may provide benefit to patients with low-to-normal LDL levels and no known cardiovascular disease.
A risk exists of muscle damage (myopathy and rhabdomyolysis) with statins. Hypercholesterolemia is not a risk factor for mortality in persons older than 70 years and risks from statin drugs are more increased after age 85. [2] Fibrates are indicated for hypertriglyceridemia. Fibrates typically lower triglycerides by 20% to 50%.
Statins are the typically used medications, in addition to healthy lifestyle interventions. [68] Statins can reduce total cholesterol by about 50% in the majority of people, [39] and are effective in reducing the risk of cardiovascular disease in both people with [69] and without pre-existing cardiovascular disease.