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Targeted alpha-particle therapy (or TAT) is an in-development method of targeted radionuclide therapy of various cancers. It employs radioactive substances which undergo alpha decay to treat diseased tissue at close proximity. [1] It has the potential to provide highly targeted treatment, especially to microscopic tumour cells.
Alpha radiation is a nuclear phenomenon in which a heavy radionuclide emits an energetic alpha particle (consisting of two protons and two neutrons) and transmutes to a different radionuclide. The emitted alpha particle has a range in tissue of only 40-90 microns, which minimizes collateral damage when used for treatment purposes.
Immutep's first Phase I study of efti in cancer patients was an open-label study in 21 metastatic renal cell carcinoma patients, with the drug being used as a monotherapy. [5] These patients were known to be immunocompromised. The study, which began in late 2005, saw the patients administered ascending doses of efti (up to 30 mg per ...
In the Nigro protocol, the patient receives 30 Gy (3000 rads) of radiation over a three-week period, as well as continuous administration of fluorouracil for the first four days and on days 20–31, with bolus mitomycin on day 1. [3] It is named after Norman Nigro (1912–2009), [4] who developed it in the mid-1970s. [5]
The majority of drugs used in cancer chemotherapy are cytostatic, many via cytotoxicity. A fundamental philosophy of medical oncology , including combination chemotherapy, is that different drugs work through different mechanisms, and that the results of using multiple drugs will be synergistic to some extent.
Anti-cancer psychotherapy – a technique [131] claiming that a "cancer personality" caused cancer, which could be cured through talk therapy (e.g. that of the Simonton Cancer Center, [132] Bernie Siegel's "Exceptional Cancer Patients" (ECaP) or Deepak Chopra). Evidence is lacking that cancer cures sold or promoted by Deepak Chopra have any value.
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As of 2019, only 32.9% of cancer patients in the United States died within five years of their diagnosis. [7] Despite their effectiveness, many conventional treatments are accompanied by a wide range of side effects, including pain, fatigue, and nausea. [8] [9] Some side effects can even be life-threatening.