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Selenium disulfide, also known as selenium sulfide, is a chemical compound and medication used to treat seborrheic dermatitis, dandruff, and pityriasis versicolor. [ 1 ] [ 2 ] It is applied to the affected area as a lotion or shampoo. [ 3 ]
Selenium sulfide slows down epidermal proliferation. It is fungicidal to Pityrosporum ovale. It also acts as a keratolytic. Selenium sulfide is also known to reduce dryness of scalp and folliculitis. [2] Systemic toxicity can appear if it is applied to inflamed skin. Hypersensitivity reactions are noted in some people.
Regular use of an over-the-counter or prescription antifungal shampoo or cream is a common treatment. The topical antifungal medications ketoconazole and ciclopirox have the best evidence. [10] Ketoconazole should be used twice per week. [8] Shampoo or soap containing zinc pyrithione or selenium disulfide is also used. [8]
Over the counter Selsun Blue contains 1% selenium sulfide as its active ingredient in its most popular version [2] (the word "Selsun" is a portmanteau of selenium sulfide + n). Chattem announced that on November 1, 2005, they would introduce a new line of shampoos under the brand name Selsun Salon.
Products made by Nature Made, CeraVe and Neutrogena had the most No. 1 rankings.
The most common side effects are irritation, stinging or burning of the skin. Other side effects include nausea, vomiting, dizziness, tiredness and headache. [2] There are however also severe side effects including severe allergic reactions, like (nettle) rash, itch, tightness in chest, difficult breathing and swelling in either the face, mouth, lips or tongue.