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Aplastic anemia is a rare, noncancerous disorder in which the blood marrow is unable to adequately produce blood cells required for survival. [44] [45] It is estimated that the incidence of aplastic anemia is 0.7–4.1 cases per million people worldwide, with the prevalence between men and women being approximately equal. [46]
Aplastic anemia is a condition where bone marrow does not produce sufficient new cells to replenish blood cells. [27] Autoimmune hemolytic anemia: D59.0-D59.1: Autoimmune hemolytic anemia (AIHA) is a type of hemolytic anemia where the body's immune system attacks its own red blood cells (RBCs), leading to their destruction .
Pure red cell aplasia (PRCA) or erythroblastopenia refers to a type of aplastic anemia affecting the precursors to red blood cells but usually not to white blood cells. In PRCA, the bone marrow ceases to produce red blood cells. There are multiple etiologies that can cause PRCA. The condition has been first described by Paul Kaznelson in 1922. [1]
In the 1990s, Young initiated and implemented a formal epidemiologic study of aplastic anemia in Thailand, which revealed a much higher incidence rate than in the West. [5] Coincidentally, he established a teaching program an NHLBI-sponsored teaching program in Vietnam, for which he later received a Government of Vietnam Service to the People ...
With isolated reticulocytopenia, the main cause is Parvovirus B19 infection of reticulocytes leading to transient anemia. [2] In patients who rely on frequent red cell regeneration e.g. sickle cell disease, a reticulocytopenia can lead to a severe anemia due to the cessation in red cell production (erythropoiesis), referred to as aplastic ...
Fanconi anemia (FA) is a rare, ... and liver tumors. 90% develop aplastic anemia (the inability to produce blood cells) by age 40. ... two-year survival rates drop to ...
Congenital amegakaryocytic thrombocytopenia (CAMT) is a rare autosomal recessive bone marrow failure syndrome characterized by severe thrombocytopenia, which can progress to aplastic anemia and leukemia. [4] CAMT usually manifests as thrombocytopenia in the initial month of life or in the fetal phase.
Infectious mononucleosis, acute myeloid leukemia, lymphoblastic lymphoma, aplastic anemia [3] Treatment: Chemotherapy, stem cell transplantation, radiation therapy, targeted therapy [7] [1] Prognosis: Children: 90% five-year survival rate [2] Adults: 35% five-year survival [8] Frequency: 1 in 1,750 children [4] [9] Deaths: 111,000 (2015) [10]