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Mederma is a topical product used to improve scar appearance. It is a gel based on an onion extract. Mederma is product of HRA Pharma, a division of Perrigo. A Mederma marketing claim is that the product can can make scars "softer, smoother, and less noticeable". [1]
The exact mechanism of action of silicone gel sheeting has not been fully studied. Currently, many proposed mechanisms explain the efficacy of such treatment, including the occlusion and hydration effect, increased body surface temperature, polarized electric charge, immunological effects, etc. [9] The occlusion and hydration effect is the most studied mechanism of action.
A hypertrophic scar is a cutaneous condition characterized by deposits of excessive amounts of collagen which gives rise to a raised scar, but not to the degree observed with keloids. [1] Like keloids, they form most often at the sites of pimples, body piercings, cuts and burns. They often contain nerves and blood vessels.
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Severe cutaneous adverse reactions (SCARs) are a group of potentially lethal adverse drug reactions that involve the skin and mucous membranes of various body openings such as the eyes, ears, and inside the nose, mouth, and lips. In more severe cases, SCARs also involves serious damage to internal organs. SCARs includes five syndromes:
Very common (≥ 1/10) Common (≥ 1/100, < 1/10) Unknown frequency Skin pain Dermatitis: Allergic reaction: Rash Facial swelling Xeroderma (dry skin) : Hives: Prunitis (skin itching)