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  2. Foreign-body giant cell - Wikipedia

    en.wikipedia.org/wiki/Foreign-body_giant_cell

    A foreign-body giant cell is a collection of fused macrophages which are generated in response to the presence of a large foreign body. This is particularly evident with catheters , parasites , or biomaterials that are inserted into the body for replacement or regeneration of diseased or damaged tissues.

  3. Foreign body reaction - Wikipedia

    en.wikipedia.org/wiki/Foreign_body_reaction

    Foreign body granuloma formation consists of protein adsorption, macrophages, multinucleated foreign body giant cells (macrophage fusion), fibroblasts, and angiogenesis. It has also been proposed that the mechanical property of the interface between an implant and its surrounding tissues is critical for the host response.

  4. Giant cell - Wikipedia

    en.wikipedia.org/wiki/Giant_cell

    A giant cell (also known as a multinucleated giant cell, or multinucleate giant cell) is a mass formed by the union of several distinct cells (usually histiocytes), often forming a granuloma. [ 1 ] Although there is typically a focus on the pathological aspects of multinucleate giant cells (MGCs), they also play many important physiological roles.

  5. Tzanck test - Wikipedia

    en.wikipedia.org/wiki/Tzanck_test

    Granuloma formation and multinucleated giant cells The main purpose of cytological examination in granulomatous dermatitis is to detect infectious agents. Foreign body materials are very specific for foreign body granuloma. Granuloma annulare: Palisading granuloma and mucin Necrobiosis lipoidica: Palisading granuloma and necrobiotic materials

  6. Multinucleate - Wikipedia

    en.wikipedia.org/wiki/Multinucleate

    Multinucleate cells (also known as multinucleated cells or polynuclear cells) are eukaryotic cells that have more than one nucleus, i.e., multiple nuclei share one common cytoplasm. Mitosis in multinucleate cells can occur either in a coordinated, synchronous manner where all nuclei divide simultaneously or asynchronously where individual ...

  7. Touton giant cell - Wikipedia

    en.wikipedia.org/wiki/Touton_giant_cell

    Touton giant cells, being multinucleated giant cells, can be distinguished by the presence of several nuclei in a distinct pattern. This pattern is described as a ring-like or wreath-like in the center of a cell. These cells contain a ring of nuclei surrounding a central homogeneous cytoplasm, while foamy cytoplasm surrounds the nuclei.

  8. Fusion mechanism - Wikipedia

    en.wikipedia.org/wiki/Fusion_mechanism

    Osteoclasts are multinucleated bone-resorbing cells. They are formed by the fusion of differentiated monocytes, much like foreign-body giant cells. However, the molecules that induce fusion-competence in macrophages that are destined to become osteoclasts are different from those that promote formation of foreign-body giant cells.

  9. Syncytium - Wikipedia

    en.wikipedia.org/wiki/Syncytium

    A syncytium (/ s ɪ n ˈ s ɪ ʃ i ə m /; pl.: syncytia; from Greek: σύν syn "together" and κύτος kytos "box, i.e. cell") or symplasm is a multinucleate cell that can result from multiple cell fusions of uninuclear cells (i.e., cells with a single nucleus), in contrast to a coenocyte, which can result from multiple nuclear divisions without accompanying cytokinesis. [1]

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