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Eliglustat, sold under the brand name Cerdelga, is a medication used for the treatment of Gaucher's disease. It was discovered at the University of Michigan, developed by Genzyme Corp, and was approved by the FDA in August 2014. [7] Commonly used as the tartrate salt, the compound is believed to work by inhibition of glucosylceramide synthase.
Around one in 100 people in the general US population is a carrier for type I Gaucher's disease, giving a prevalence of one in 40,000. [40] Among Ashkenazi Jews, the rate of carriers is considerably higher, at roughly one in 15. [40] Type II Gaucher's disease shows no particular preference for any ethnic group. [citation needed]
Severe gingivitis in dogs can further advance into periodontal disease in which the periodontal tissues begin to degrade and, if left untreated, can lead to tooth loss. [11] Studies have also shown that periodontal disease can negatively affect systemic health which impacts the overall health of the dog, therefore exhibiting the importance of ...
Enzyme replacement therapy is available to treat mainly Fabry disease and Gaucher disease, and people with these types of sphingolipidoses may live well into adulthood. The other types are generally fatal by age 1 to 5 years for infantile forms, but progression may be mild for juvenile- or adult-onset forms.
In this treatment, the accumulated compounds are inhibited from forming in the body of a patient with a lysosomal storage disease. [10] The accumulated compounds are responsible for the symptoms of these disorders, and they form via a multi-step biological pathway. [ 10 ]
Hypoallergenic diets for dogs with food allergies consist of either limited ingredients, [86] novel proteins, [83] or hydrolyzed proteins. [87] Limited ingredients make it possible to identify the suspected allergens causing these allergic reactions, as well as making it easy to avoid multiple ingredients if a canine is allergic to more than ...
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