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Megaloblastic anaemia; Methaemoglobinaemia; Erythema multiforme; Low blood sugar; Hepatitis (liver swelling); Crystalluria (crystals in the urine); Urinary obstruction causing difficulty passing urine
The legs and face are the most common sites involved, although cellulitis can occur on any part of the body. [1] The leg is typically affected following a break in the skin. [1] Other risk factors include obesity, leg swelling, and old age. [1] For facial infections, a break in the skin beforehand is not usually the case. [1]
The effects of trimethoprim causes a backlog of dihydrofolate (DHF) and this backlog can work against the inhibitory effect the drug has on tetrahydrofolate biosynthesis. This is where the sulfamethoxazole comes in; its role is in depleting the excess DHF by preventing it from being synthesised in the first place. [14]
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Leg edema Peripheral edema is edema (accumulation of fluid causing swelling) in tissues perfused by the peripheral vascular system , usually in the lower limbs . In the most dependent parts of the body (those hanging distally ), it may be called dependent edema.
The area of redness often extends beyond the swelling. [8] Carbuncles and boils are types of abscess that often involve hair follicles, with carbuncles being larger. [9] A cyst is related to an abscess, but it contains a material other than pus, and a cyst has a clearly defined wall. Abscesses can also form internally on internal organs and ...
When symptoms grow worse (more on this later), heart failure can cause swelling in the ankles and legs, as well as swollen feet. This is due to edema, which is a fluid accumulation in the body ...
Sulfamethoxazole (SMZ or SMX) is an antibiotic.It is used for bacterial infections such as urinary tract infections, bronchitis, and prostatitis and is effective against both gram negative and positive bacteria such as Escherichia coli and Listeria monocytogenes.