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The Akt-PI3K pathway is essential for cell survival as activated Akt influences many factors involved in apoptosis, either by transcription regulation or direct phosphorylation. [ 5 ] In the nucleus, Akt inhibits transcription factors that promote the expression of cell death genes, and enhances transcription of anti-apoptotic genes.
The PI3K pathway also recruits many other proteins downstream, including mTOR, [29] GSK3β, [30] and PSD-95. [29] The PI3K-mTOR pathway leads to the phosphorylation of p70S6K, a kinase that facilitates translational activity, [31] [32] further suggesting that PI3Ks are required for the protein-synthesis phase of LTP induction instead.
mTOR signaling pathway. The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. PI3K activation phosphorylates and activates AKT, localizing it in the plasma membrane. [1]
The 5-HT 1 receptors are a subfamily of the 5-HT serotonin receptors that bind to the endogenous neurotransmitter serotonin (also known as 5-hydroxytryptamine, or 5-HT). [1] The 5-HT 1 subfamily consists of five G protein-coupled receptors (GPCRs) that share 40% to 63% overall sequence homology, including 5-HT 1A, 5-HT 1B, 5-HT 1D, 5-HT 1E, and 5-HT 1F. [2]
Serotonin pathways are thought to modulate eating, both the amount as well as the motor processes associated with eating. The serotonergic projections into the hypothalamus are thought to be particularly relevant, and an increase in serotonergic signaling is thought to generally decrease food consumption (evidenced by fenfluramine , however ...
In cell biology, there are a multitude of signalling pathways. Cell signalling is part of the molecular biology system that controls and coordinates the actions of cells. Akt/PKB signalling pathway
15550 Ensembl ENSG00000178394 ENSMUSG00000021721 UniProt P08908 Q64264 RefSeq (mRNA) NM_000524 NM_008308 RefSeq (protein) NP_000515 NP_032334 Location (UCSC) Chr 5: 63.96 – 63.96 Mb Chr 13: 105.58 – 105.58 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The serotonin 1A receptor (or 5-HT 1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin ...
Phosphoinositide-3-kinase (PI3K) activates an important cell survival signaling pathway, and constitutive activation is seen in ovarian, head and neck, urinary tract, cervical and small cell lung cancer. PI3K signaling is attenuated by the phosphatase activity of the tumor suppressor PTEN that is absent in a number of human cancers.