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Lacosamide, sold under the brand name Vimpat among others, is a medication used for the treatment of partial-onset seizures and primary generalized tonic-clonic seizures. [2] It is used by mouth or intravenously .
Levetiracetam, sold under the brand name Keppra among others, is a novel antiepileptic drug [7] used to treat epilepsy. [8] It is used for partial-onset , myoclonic , or tonic–clonic seizures, [ 7 ] and is taken either by mouth as an immediate or extended release formulation or by injection into a vein .
Based on the 2010 guidelines from the International League against Epilepsy (ILAE), DRE is officially diagnosed following a lack of therapeutic relief in the form of continued seizure burden after trialing at least two antiepileptic drugs (AEDs) at the appropriate dosage and duration. [1] [2] The probability that the next medication will ...
Drug titration is the process of adjusting the dose of a medication for the maximum benefit without adverse effects. [1] When a drug has a narrow therapeutic index, titration is especially important, because the range between the dose at which a drug is effective and the dose at which side effects occur is small. [2]
Seletracetam (UCB 44212) is a pyrrolidone-derived [2] drug of the racetam family that is structurally related to levetiracetam (trade name Keppra). [ 2 ] [ 3 ] It was under development by UCB Pharmaceuticals as a more potent and effective anticonvulsant drug to replace levetiracetam but its development has been halted.
Dogs with rage syndrome typically have their first rage episode during adolescence, between 1 and 3 years old, similar to dogs with idiopathic epilepsy. [1] Interictal EEGs under general anesthesia typically show low-voltage rapid discharges characteristic of focal seizures. [1] [11] [12] Seizure foci are in the temporal lobe, most often the ...
Data are based on moderate quality evidence. RR 1.31 (1.16 to 1.47) Moderate: Leaving the study early for any reason: Valproate in combination with antipsychotics may slightly reduce the chance of leaving the study early, but the difference between the two treatments is not clear. Data supporting this finding are based on moderate quality evidence.
Potassium bromide is used in veterinary medicine to treat epilepsy in dogs, either as first-line treatment or in addition to phenobarbital, when seizures are not adequately controlled with phenobarbital alone. [5] Use of bromide in cats is limited because it carries a substantial risk of causing lung inflammation (pneumonitis) in them.