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Shiga-like toxin (SLT) is a historical term for similar or identical toxins produced by Escherichia coli. [3] The most common sources for Shiga toxin are the bacteria S. dysenteriae and some serotypes of Escherichia coli (shigatoxigenic or STEC), which include serotypes O157:H7 , and O104:H4 .
The Shiga toxins target ribosomal RNA, which inhibits protein synthesis and causes apoptosis. [14] The reason EHEC are symptomless in cattle is because the cattle do not have vascular expression of Gb3 unlike humans. Thus, the Shiga toxins cannot pass through the intestinal epithelium into circulation. [5]
Escherichia coli O157:H7 is a serotype of the bacterial species Escherichia coli and is one of the Shiga-like toxin–producing types of E. coli.It is a cause of disease, typically foodborne illness, through consumption of contaminated and raw food, including raw milk and undercooked ground beef.
Tests for toxin production can use mammalian cells in tissue culture, which are rapidly killed by shiga toxin. Although sensitive and very specific, this method is slow and expensive. [49] Typically, diagnosis has been done by culturing on sorbitol-MacConkey medium and then using typing antiserum.
This allows the body to detect the harmful toxin if it is encountered later, and to eliminate it before it can cause harm to the host. Toxins of this type include cholera toxin, pertussis toxin, Shiga toxin and heat-labile enterotoxin from E. coli.
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Escherichia coli O121 is a pathogenic serotype of Escherichia coli, [1] associated with Shiga toxin, intestinal bleeding, and hemolytic-uremic syndrome (HUS). [2] HUS, if left untreated, can lead to kidney failure. [citation needed]