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A large number of hierarchies of evidence have been proposed. Similar protocols for evaluation of research quality are still in development. So far, the available protocols pay relatively little attention to whether outcome research is relevant to efficacy (the outcome of a treatment performed under ideal conditions) or to effectiveness (the outcome of the treatment performed under ordinary ...
In 1965, the English statistician Sir Austin Bradford Hill proposed a set of nine criteria to provide epidemiologic evidence of a causal relationship between a presumed cause and an observed effect. (For example, he demonstrated the connection between cigarette smoking and lung cancer.) The list of the criteria is as follows: [1]
Given their intrinsic methodological limitations, including lack of statistical sampling, case reports are placed at the bottom of the hierarchy of clinical evidence, together with case series. [3] Nevertheless, case reports do have genuinely useful roles in medical research and evidence-based medicine. [4]
Alternatively, one could group subjects based on their body mass index (BMI) and compare their risk of developing heart disease or cancer. Prospective cohort studies are typically ranked higher in the hierarchy of evidence than retrospective cohort studies [3] and can be more expensive than a case–control study. [4]
It was argued that PICO may be useful for every scientific endeavor even beyond clinical settings. [2] This proposal is based on a more abstract view of the PICO mnemonic, equating them with four components that is inherent to every single research, namely (1) research object; (2) application of a theory or method; (3) alternative theories or methods (or the null hypothesis); and (4) the ...
A systematic review is a scholarly synthesis of the evidence on a clearly presented topic using critical methods to identify, define and assess research on the topic. [1] A systematic review extracts and interprets data from published studies on the topic (in the scientific literature), then analyzes, describes, critically appraises and summarizes interpretations into a refined evidence-based ...
An integrated outline is a helpful step in the process of organizing and writing a scholarly paper (literature review, research paper, thesis or dissertation). When completed the integrated outline contains the relevant scholarly sources (author's last name, publication year, page number if quote) for each section in the outline.
[1] [2] Hierarchy of study design, for example using a case-study, ecological study, cross-sectional, case-control, cohort, or experimental, although not always in this order is a general rule to a high "strength of evidence" of a clinical study. [3] [4] [5]