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  2. Autoimmune hypophysitis - Wikipedia

    en.wikipedia.org/wiki/Autoimmune_hypophysitis

    Likewise, 20% of autoimmune thyroid patients also have pituitary antibodies. [7] It follows that a subset of thyroid patients may have a disease related to autoimmune hypophysitis. Recent research has focused on a defect at the CTLA-4 gene which, coupled with other factors, may result in autoimmunity primarily focusing on certain endocrine ...

  3. Hypothyroidism - Wikipedia

    en.wikipedia.org/wiki/Hypothyroidism

    In 1971, the thyroid stimulating hormone (TSH) radioimmunoassay was developed, which was the most specific marker for assessing thyroid status in patients. [82] Many people who were being treated based on basal metabolic rate, minimizing hypothyroid symptoms, or based on serum protein-bound iodine, were found to have excessive thyroid hormone. [82]

  4. Levothyroxine - Wikipedia

    en.wikipedia.org/wiki/Levothyroxine

    For older people (over 50 years old) and people with known or suspected ischemic heart disease, levothyroxine therapy should not be initiated at the full replacement dose. [24] Since thyroid hormone increases the heart's oxygen demand by increasing heart rate and contractility, starting at higher doses may cause an acute coronary syndrome or an ...

  5. Hashimoto's thyroiditis - Wikipedia

    en.wikipedia.org/wiki/Hashimoto's_thyroiditis

    As the free amount reflects the amount available to body tissues, the most treatment-relevant measures for thyroid disorders are Free T 3 and Free T 4. [68] Typically, Free T 4 is the preferred test for hypothyroidism, [ 69 ] as Free T 3 immunoassay tests are less reliable at detecting low levels of thyroid hormone, [ 70 ] and they are more ...

  6. Thyroid hormones - Wikipedia

    en.wikipedia.org/wiki/Thyroid_hormones

    TPO also converts tyrosyl, MIT-yl, and DIT-yl residues into their free radical forms. These forms attack other MIT-yl and DIT-yl residues. When a DIT-yl radical attacks a DIT, T 4-yl (peptidic T 4) is formed. When a MIT-yl radical attacks a DIT, T 3-yl is formed. Other reactions are possible, but do not form physiologically active products. [40 ...

  7. Thyroid disease in women - Wikipedia

    en.wikipedia.org/wiki/Thyroid_disease_in_women

    Over time, thyroid damage can cause thyroid hormone levels to be too low. This is called an underactive thyroid or hypothyroidism (heye-poh-THEYE-royd-ism). An underactive thyroid causes every function of the body to slow down, such as heart rate, brain function, and the rate your body turns food into energy.

  8. Hyperthyroidism - Wikipedia

    en.wikipedia.org/wiki/Hyperthyroidism

    In addition to testing the TSH levels, many doctors test for T 3, Free T 3, T 4, and/or Free T 4 for more detailed results. Free T 4 is unbound to any protein in the blood. Adult limits for these hormones are: TSH (units): 0.45 – 4.50 uIU/mL; T 4 Free/Direct (nanograms): 0.82 – 1.77 ng/dl; and T 3 (nanograms): 71 – 180 ng

  9. Broda Otto Barnes - Wikipedia

    en.wikipedia.org/wiki/Broda_Otto_Barnes

    Broda Otto Barnes (14 April 1906 – 1 November 1988) was an American physician and professor of medicine who studied endocrine dysfunction, particularly hypothyroidism. [4] [5] In the 1970s, Barnes published several books arguing that hypothyroidism was underdiagnosed in the U.S. and was responsible for a wide range of health problems.