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Toxicodynamics, termed pharmacodynamics in pharmacology, describes the dynamic interactions of a toxicant with a biological target and its biological effects. [1] A biological target , also known as the site of action, can be binding proteins, ion channels , DNA , or a variety of other receptors.
Toxicodynamics (TD) and pharmacodynamics (PD) link a therapeutic agent or toxicant, or toxin (xenobiotic)'s dosage to the features, amount, and time course of its biological action. [11] The mechanism of action is a crucial factor in determining effect and toxicity of the drug, taking in consideration the pharmacokinetic (PK) factors. [ 12 ]
It is an application of pharmacokinetics to determine the relationship between the systemic exposure of a compound and its toxicity.It is used primarily for establishing relationships between exposures in toxicology experiments in animals and the corresponding exposures in humans.
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CNET Download (originally Download.com) is an Internet download directory website launched in 1996 as a part of CNET. Initially it resided on the domain download.com, and then download.com.com for a while, and is now download.cnet.com. The domain download.com attracted at least 113 million visitors annually by 2008 according to a Compete.com ...
Chuck Huber is an American voice actor. He has provided numerous voices for Japanese anime series and video games. He is best known for his roles as Hiei in Yu Yu Hakusho, Dr. Franken Stein in Soul Eater, Pilaf in Dragon Ball, Shou Tucker in Fullmetal Alchemist, Android #17 in Dragon Ball Z and Turner Grey in Ace Attorney.
Crunchyroll has streamed the series internationally. [1] Sentai Filmworks has licensed the anime for digital and home video release in North America with an English dub released in March 2017. [ 2 ] [ 3 ] The first original video animation was released on December 7, 2016.
John Allan Swasey [1] is an American voice actor, ADR director, and screenwriter. He has provided voices for English-language versions of Japanese anime series and video games. His most notable roles include Gendo Ikari in the Rebuild of Evangelion films, Sir Crocodile in the Funimation dub of One Piece , Lord Death in Soul Eater , Van ...