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The side effects of ketoconazole are sometimes harnessed in the treatment of non-fungal conditions. While ketoconazole blocks the synthesis of the sterol ergosterol in fungi, in humans, at high dosages (>800 mg/day), it potently inhibits the activity of several enzymes necessary for the conversion of cholesterol to steroid hormones such as ...
Due to its feminising side effects and risk of infertility it is not often used by men. [ 32 ] [ 33 ] It can also cause low blood pressure , high blood potassium , and abnormal heart rhythms . Also, women who are pregnant or trying to become pregnant generally cannot use the medication as it is a teratogen , and can cause ambiguous genitalia in ...
The side effects of oral treatment are significant and people without an infection should not take these drugs. [36] Azoles are the group of antifungals which act on the cell membrane of fungi. They inhibit the enzyme 14-alpha-sterol demethylase, a microsomal CYP, which is required for the biosynthesis of ergosterol for the cytoplasmic membrane.
In the 2019 study we mentioned earlier comparing ketoconazole shampoo to minoxidil, only 10 percent of people reported side effects from ketoconazole. But like all medications, ketoconazole comes ...
There are some cosmetic side effects of ketoconazole as well, including making hair dry or oily (could go either way) or stripping colored hair. Oral ketoconazole has side effects too.
Antiglucocorticoid drugs are a class of medications that act to reduce the effects of glucocorticoids, primarily cortisol, in the body. [1] They include direct glucocorticoid receptor antagonists such as mifepristone and synthesis inhibitors such as metyrapone, ketoconazole, and aminoglutethimide. They are used to treat Cushing's syndrome. [2]