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The underlying cause of the Bowditch effect is an increase in the calcium concentration in the sarcoplasmic reticulum of cardiac muscle cells, and its increased release into sarcoplasm. [ 3 ] One of the explanations for an increase in the intracellular calcium concentration is the inability of the Na + /K + -ATPase to keep up with influx of ...
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Pre-test probability: For example, if about 2 out of every 5 patients with abdominal distension have ascites, then the pretest probability is 40%. Likelihood Ratio: An example "test" is that the physical exam finding of bulging flanks has a positive likelihood ratio of 2.0 for ascites.
False positives "can happen with any test" and, if someone tests positive for COVID-19 with a rapid test but does not have symptoms, he recommends following up with a PCR test to confirm that this ...
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The government has published Bowditch ever since. George Blunt died in 1878. Nathaniel Bowditch continued to correct and revise the book until his death in 1838. Upon his death, the editorial responsibility for The New American Practical Navigator passed to his son, J. Ingersoll Bowditch. Very few significant changes were made under him.