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Sarilumab, sold under the brand name Kevzara, is a human monoclonal antibody medication against the interleukin-6 receptor. [6] Regeneron Pharmaceuticals and Sanofi developed the drug for the treatment of rheumatoid arthritis (RA), for which it received US FDA approval on 22 May 2017 and European Medicines Agency approval on 23 June 2017.
Paclitaxel has also been used in vitro to inhibit insulin fibrillation. In a molar ratio of 10:1 (insulin:paclitaxel), it hindered insulin fibrillation near 70%. Isothermal titration calorimetry (ITC) findings indicated a spontaneous tendency of paclitaxel to interact with insulin through hydrogen bonds and van der Waals forces. [78]
For example, in standard treatment of ovarian cancer, paclitaxel is given at 175 mg/m 2 body surface every three weeks. In dose dense therapy paclitaxel is given at 50–80 mg/m 2 every week (150–240 mg/m 2 in 3-weeks). [2]
Simple blood tests are also available for dose optimization of methotrexate, [32] 5-FU, paclitaxel, and docetaxel. [ 33 ] [ 34 ] The serum albumin level immediately prior to chemotherapy administration is an independent prognostic predictor of survival in various cancer types.
Protein-bound paclitaxel, also known as nanoparticle albumin–bound paclitaxel or nab-paclitaxel, is an injectable formulation of paclitaxel used to treat breast cancer, lung cancer and pancreatic cancer, among others. Paclitaxel kills cancer cells by preventing the normal breakdown of microtubules during cell division.
DHA-paclitaxel (or Taxoprexin) is an investigational drug (from Protarga Inc) made by linking paclitaxel to docosahexaenoic acid (DHA), a fatty acid that is easily taken up by tumor cells; the DHA-paclitaxel “appears not to be cytotoxic until the bond with DHA is cleaved within the cell.” [1] The advantage of DHA-paclitaxel over paclitaxel is DHA-paclitaxel's ability to carry much higher ...
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