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S100 calcium-binding protein B (S100B) is a protein of the S100 protein family. S100 proteins are localized in the cytoplasm and nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a ...
The S100 proteins are a family of low molecular-weight proteins found in vertebrates characterized by two calcium-binding sites that have helix-loop-helix ("EF-hand-type") conformation. At least 21 different S100 proteins are known. [1] They are encoded by a family of genes whose symbols use the S100 prefix, for example, S100A1, S100A2, S100A3.
Lecanemab, sold under the brand name Leqembi, is a monoclonal antibody medication used for the treatment of Alzheimer's disease. [2] [4] Lecanemab is an amyloid beta-directed antibody. [2] It is given via intravenous infusion to patients with mild cognitive impairment or mild dementia. [2]
Aducanumab, sold under the brand name Aduhelm, is a monoclonal antibody designed to treat Alzheimer's disease. It is a monoclonal antibody that targets aggregated forms (plaque) of amyloid beta (Aβ) found in the brains of people with Alzheimer's disease to reduce its buildup. [10] It was developed by Biogen and Eisai. [11] Aducanumab is given via intravenous infusion. [5] Aducanumab was ...
This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.
6275 20198 Ensembl ENSG00000196154 ENSMUSG00000001020 UniProt P26447 P07091 RefSeq (mRNA) NM_019554 NM_002961 NM_011311 RefSeq (protein) NP_002952 NP_062427 NP_035441 Location (UCSC) Chr 1: 153.54 – 153.55 Mb Chr 3: 90.51 – 90.51 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein S100-A4 (S100A4) is a protein that in humans is encoded by the S100A4 gene. Function The protein ...
The advantage of active monoclonal antibody therapy is the fact that the immune system will produce antibodies long-term, with only a short-term drug administration to induce this response. However, the immune response to certain antigens may be inadequate, especially in the elderly.
It is a monoclonal antibody that targets calcitonin gene-related peptides (CGRP) alpha and beta. [6] [8] It is administered by intravenous infusion. [6] Eptinezumab was approved for medical use in the United States in February 2020, [9] [10] and in the European Union in January 2022. [7] [11]