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  2. High-performance liquid chromatography - Wikipedia

    en.wikipedia.org/wiki/High-performance_liquid...

    They are analogous to the calculation of retention factor for a paper chromatography separation, but describes how well HPLC separates a mixture into two or more components that are detected as peaks (bands) on a chromatogram. The HPLC parameters are the: efficiency factor(N), the retention factor (kappa prime), and the separation factor (alpha ...

  3. Area under the curve (pharmacokinetics) - Wikipedia

    en.wikipedia.org/wiki/Area_under_the_curve...

    The use of trapezoidal rule in AUC calculation was known in literature by no later than 1975, in J.G. Wagner's Fundamentals of Clinical Pharmacokinetics. A 1977 article compares the "classical" trapezoidal method to a number of methods that take into account the typical shape of the concentration plot, caused by first-order kinetics. [8]

  4. Charged aerosol detector - Wikipedia

    en.wikipedia.org/wiki/Charged_Aerosol_Detector

    The charged aerosol detector (CAD) is a detector used in conjunction with high-performance liquid chromatography (HPLC) and ultra high-performance liquid chromatography (UHPLC) to measure the amount of chemicals in a sample by creating charged aerosol particles which are detected using an electrometer.

  5. Partition coefficient - Wikipedia

    en.wikipedia.org/wiki/Partition_coefficient

    Partition coefficients can be measured experimentally in various ways (by shake-flask, HPLC, etc.) or estimated by calculation based on a variety of methods (fragment-based, atom-based, etc.). If a substance is present as several chemical species in the partition system due to association or dissociation, each species is assigned its own K ow ...

  6. Resolution (chromatography) - Wikipedia

    en.wikipedia.org/wiki/Resolution_(chromatography)

    Chromatographic peak resolution is given by = + where t R is the retention time and w b is the peak width at baseline. The bigger the time-difference and/or the smaller the bandwidths, the better the resolution of the compounds.

  7. Assay - Wikipedia

    en.wikipedia.org/wiki/Assay

    An assay (analysis) is never an isolated process, as it must be accompanied with pre- and post-analytic procedures. Both the communication order (the request to perform an assay plus related information) and the handling of the specimen itself (the collecting, documenting, transporting, and processing done before beginning the assay) are pre-analytic steps.

  8. Internal standard - Wikipedia

    en.wikipedia.org/wiki/Internal_standard

    The coefficient of determination (R 2) for this plot is 0.9985. In the calibration curve that uses the internal standard, the y-axis is the ratio of the nickel signal to the yttrium signal. This ratio is unaffected by uncertainty in the nickel measurements, as it should affect the yttrium measurements in the same way.

  9. Detection limit - Wikipedia

    en.wikipedia.org/wiki/Detection_limit

    Most analytical instruments produce a signal even when a blank (matrix without analyte) is analyzed.This signal is referred to as the noise level. The instrument detection limit (IDL) is the analyte concentration that is required to produce a signal greater than three times the standard deviation of the noise level.