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Angle-resolved low-coherence interferometry (a/LCI) is an emerging [when?] biomedical imaging technology which uses the properties of scattered light to measure the average size of cell structures, including cell nuclei. The technology shows promise as a clinical tool for in situ detection of dysplastic, or precancerous tissue.
Figure 2. File:Twyman-Green interferometer set up as a white light scanner. Vertical scanning interferometry is an example of low-coherence interferometry, which exploits the low coherence of white light. Interference will only be achieved when the path length delays of the interferometer are matched within the coherence time of the light source.
Optical coherence tomogram of a fingertip. It is possible to observe the sweat glands, having "corkscrew appearance" Interferometric reflectometry of biological tissue, especially of the human eye using short-coherence-length light (also referred to as partially-coherent, low-coherence, or broadband, broad-spectrum, or white light) was investigated in parallel by multiple groups worldwide ...
This axial shift will make photons appear like they appear deeper from the sample than they actually are. The presence of multiple scattering events causes a distribution of path lengths that intrinsically blurs the image, resulting in a maximum millimeter-scale resolution which is substantially poorer than OCT which operates at a micrometer ...
Optical coherence tomography (OCT) is a medical imaging technique using low-coherence interferometry to provide tomographic visualization of internal tissue microstructures. As seen in Fig. 22, the core of a typical OCT system is a Michelson interferometer.
Spectroscopic optical coherence tomography (SOCT) is an optical imaging and sensing technique, which provides localized spectroscopic information of a sample based on the principles of optical coherence tomography (OCT) and low coherence interferometry. The general principles behind SOCT arise from the large optical bandwidths involved in OCT ...
Dual-axis architecture with coherence imaging was introduced in the early 2010s. Prior to the development of DA-OCT, the dual-axis design was commonly used with multiple-scattering multispectral low coherence interferometry (ms2/LCI), a technique that also analyzes multiply scattered light to take depth-resolved images from optical scattering ...
The coherence length determines the width of the correlogram, which relies on the spectral width of the light source, as well as on structural aspects such as the spatial coherence of the light source and the numerical aperture (NA) of the optical system. The following discussion assumes that the dominant contribution to the coherence length is ...