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Acute megakaryoblastic leukemia (AMKL) is life-threatening leukemia in which malignant megakaryoblasts proliferate abnormally and injure various tissues. Megakaryoblasts are the most immature precursor cells in a platelet-forming lineage; they mature to promegakaryocytes and, ultimately, megakaryocytes which cells shed membrane-enclosed particles, i.e. platelets, into the circulation.
Megakaryoblasts typically have a large oval-shaped nucleus or a nucleus that is lobed with many nuclei. [2] The megakaryoblast resembles the myeloblast or lymphoblast morphologically; however the megakaryoblast varies in phenotype and the structure viewed with electron microscopy.
Heilmeyer-Schöner disease: Acute megakaryoblastic leukemia: D007947 Acute megakaryoblastic leukemia (AMKL) is a form of acute myeloid leukemia where megakaryoblasts account for approximately 30% of the nucleated cells within the bone marrow. [81] Mast cell leukemia: Panmyelosis: C94.4: Acute panmyelosis with myelofibrosis: C94.4
This article provides a list of autoimmune diseases. These conditions, where the body's immune system mistakenly attacks its own cells, affect a range of organs and systems within the body. Each disorder is listed with the primary organ or body part that it affects and the associated autoantibodies that are typically found in people diagnosed ...
Doss porphyria/ALA dehydratase deficiency/Plumboporphyria (the disease is known by multiple names) ALD Alcoholic liver disease: ALI Acute lung injury: ALL Acute lymphoblastic lymphoma, acute lymphocytic leukemia: ALS Amyotrophic lateral sclerosis: AMD Age-related macular degeneration: AML Acute myelogenous leukemia: AN Anorexia nervosa: AOCD
Example of platelets release in mature megakaryocytes. This footage shows the formation and spontaneous release of platelets (small round-shaped blood cells), imaged with a live-cell imaging microscope. Thrombopoietin (TPO) is a 353-amino acid protein encoded on chromosome 3p27.
The more aggressive forms of disease require treatment with chemotherapy, radiotherapy, immunotherapy and—in some cases—a bone marrow transplant. The use of rituximab has been established for the treatment of B-cell–derived hematologic malignancies, including follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL).
In medicine, describing a disease as acute denotes that it is of recent onset; it occasionally denotes a short duration.The quantification of how much time constitutes "short" and "recent" varies by disease and by context, but the core denotation of "acute" is always qualitatively in contrast with "chronic", which denotes long-lasting disease (for example, in acute leukaemia and chronic ...