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A summary of CHOP upstream and downstream pathways. The PERK-ATF4-CHOP pathway can induce apoptosis by binding to the death receptors and upregulating the expression of death receptor 4 (DR4) and DR5. CHOP also interacts with the phosphorylated transcription factor JUN to form a complex that binds to the promoter region of DR4 in lung cancer ...
Hence, the TVS has provided a template for migraine pathophysiology and target for drug discovery. The history of some discoveries re the TV System are summarised in Ashina, et al. [13] The Brain Prize for 2021 was awarded to 4 investigators studying the trigeminovascular system and its implications for migraine pathophysiology and treatments.
Memory is a complex system that relies on interactions between many distinct parts of the brain. In order to fully understand memory, researchers must cumulate evidence from human, animal, and developmental research in order to make broad theories about how memory works. Intraspecies comparisons are key.
Dopaminergic pathways (dopamine pathways, dopaminergic projections) in the human brain are involved in both physiological and behavioral processes including movement, cognition, executive functions, reward, motivation, and neuroendocrine control. [1] Each pathway is a set of projection neurons, consisting of individual dopaminergic neurons.
This model is the Integrate-and-Fire (IF) model that was mentioned in Section 2.3. Closely related to IF model is a model called Spike Response Model (SRM) (Gerstner, W. (1995) [15] Pages 738-758) that is dependent on impulse function response convoluted with the input stimulus signal. This forms a base for a large number of models developed ...
The working memory model. In 1974 Baddeley and Hitch proposed a "working memory model" that replaced the general concept of short-term memory with active maintenance of information in short-term storage. In this model, working memory consists of three basic stores: the central executive, the phonological loop, and the visuo-spatial sketchpad.
Declarative memory consists of semantic memory and episodic memory.Semantic memory refers to acquired facts and general knowledge about the world. Examples include the name and physical attributes of objects and events, origins and history of objects, causes and effects of events or objects, associations between concepts, categories, opinions, beliefs, knowledge of historical events, etc. [2 ...
Long-term memory (LTM) is the stage of the Atkinson–Shiffrin memory model in which informative knowledge is held indefinitely. It is defined in contrast to sensory memory , the initial stage, and short-term or working memory , the second stage, which persists for about 18 to 30 seconds.