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The effects of trimethoprim causes a backlog of dihydrofolate (DHF) and this backlog can work against the inhibitory effect the drug has on tetrahydrofolate biosynthesis. This is where the sulfamethoxazole comes in; its role is in depleting the excess DHF by preventing it from being synthesised in the first place. [14]
Urinary tract infection in pediatric patients is a significant clinical issue, affecting approximately 7% of fevered infants and children. [43] If left untreated, the infection can ascend from the bladder to the kidneys, resulting in acute pyelonephritis, which leads to hypertension , kidney scarring , and end-stage kidney disease .
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Long-acting, broad-spectrum antibiotics offer the following advantages by comparison to short-acting antimicrobials in perioperative prophylaxis: [citation needed] A single dose covers the whole perioperative risk period - even if the operation is delayed or long-lasting - and with regard to respiratory and urinary tract infections
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The leftover antibiotic you have from your UTI, isn't going to work for your sinus infection. Consult a doctor, and if you have "leftover antibiotics" to begin with, you weren't taking them correctly.