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Signs and symptoms. Frontotemporal dementia is an early onset disorder that mostly occurs between the ages of 45 and 65, [13] but can begin earlier, and in 20–25% of cases onset is later. [11][14] Men and women appear to be equally affected. [15] It is the most common early presenting dementia. [16]
Frontal lobe disorder, also frontal lobe syndrome, is an impairment of the frontal lobe of the brain due to disease or frontal lobe injury. [5] The frontal lobe plays a key role in executive functions such as motivation, planning, social behaviour, and speech production. Frontal lobe syndrome can be caused by a range of conditions including ...
Aging brain. Aging of the brain is a process of transformation of the brain in older age, including changes all individuals experience and those of illness (including unrecognised illness). Usually this refers to humans. Since life extension is only pertinent if accompanied by health span extension, and, more importantly, by preserving brain ...
Cerebral atrophy is a common feature of many of the diseases that affect the brain. [ 1 ] Atrophy of any tissue means a decrement in the size of the cell, which can be due to progressive loss of cytoplasmic proteins. In brain tissue, atrophy describes a loss of neurons and the connections between them. Brain atrophy can be classified into two ...
Dysexecutive syndrome (DES) consists of a group of symptoms, [1] usually resulting from brain damage, that fall into cognitive, behavioural and emotional categories and tend to occur together. The term was introduced by Alan Baddeley [2][3] to describe a common pattern of dysfunction in executive functions, such as planning, abstract thinking ...
Frontotemporal lobar degeneration (FTLD) is a pathological process that occurs in frontotemporal dementia. It is characterized by atrophy in the frontal lobe and temporal lobe of the brain, with sparing of the parietal and occipital lobes. [1][2] Common proteinopathies that are found in FTLD include the accumulation of tau proteins and TAR DNA ...
Vascular dementia. Vascular dementia is dementia caused by a series of strokes. [ 2 ][ 4 ] Restricted blood flow due to strokes reduces oxygen and glucose delivery to the brain, causing cell injury and neurological deficits in the affected region. [ 6 ] Subtypes of vascular dementia include subcortical vascular dementia, multi-infarct dementia ...
The acronym LATE stands for L imbic-predominant A ge-related T DP-43 E ncephalopathy. “ Limbic ” is related to the brain areas first involved, “age-related” and the name “LATE” itself refer to the onset of disease usually in persons aged 80 or older. “ TDP-43 ” indicates the aberrant mis-folded protein (or proteinopathy ...