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[15] [12] [13] The elimination half-life of mCPP is 2.6 to 16.0 hours and is longer than that of trazodone. [ 11 ] [ 12 ] [ 14 ] Metabolites are conjugated to gluconic acid or glutathione and around 70 to 75% of 14 C-labelled trazodone was found to be excreted in the urine within 72 hours. [ 125 ]
Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma. [1][2][3][4][5] It is denoted by the abbreviation . [2][4] This is used to measure the removal of ...
Acepromazine, acetopromazine, or acetylpromazine (commonly known as ACP, Ace, or by the trade names Atravet or Acezine 2, number depending on mg/ml dose) is a phenothiazine derivative antipsychotic drug. It was used in humans during the 1950s as an antipsychotic, [4] but is now almost exclusively used on animals as a sedative and antiemetic.
It has a relatively short elimination half-life, with the reported average value of 5 to 7 hours. [90] Because of its short elimination half-life, gabapentin must be administered 3 to 4 times per day to maintain therapeutic levels. [96] Gabapentin XR (brand name Gralise) is taken once a day. [97]
[23] [15] Similarly, the terminal half-life of gabapentin enacarbil IR (as active gabapentin) is short at approximately 4.5 to 6.5 hours. [27] Because of its short elimination half-life, gabapentin must be administered 3 to 4 times per day to maintain therapeutic levels. [ 24 ]
Atipamezole. Atipamezole , sold under the brand name Antisedan among others, is a synthetic α 2 adrenergic receptor antagonist used for the reversal of the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. Its reversal effect works by competing with the sedative for α 2 -adrenergic receptors and displacing them.