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Illustration of an activator. In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. [ 1 ][ 2 ] The function of TFs is to regulate—turn on and off—genes in order ...
Half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function. IC 50 is a quantitative measure that indicates how much of a particular inhibitory substance (e.g. drug) is needed to inhibit, in vitro, a given biological process or biological component by 50% ...
See also: Reprogramming. A scheme of the generation of induced pluripotent stem (IPS) cells. (1) Isolate and culture donor cells. (2) Transduce stem cell-associated genes into the cells by viral vectors. Red cells indicate the cells expressing the exogenous genes. (3) Harvest and culture the cells according to ES cell culture, using mitotically ...
The pharmacological definition cannot apply to these substances because utilization and absorption is a function of the nutritional status and physiological state of the subject, [10] resulting in even greater differences from individual to individual (inter-individual variation). Therefore, bioavailability for dietary supplements can be ...
Nutritional science is the study of nutrition, though it typically emphasizes human nutrition. The type of organism determines what nutrients it needs and how it obtains them. Organisms obtain nutrients by consuming organic matter, consuming inorganic matter, absorbing light, or some combination of these.
Evolution is the change in the heritable characteristics of biological populations over successive generations. [1] [2] It occurs when evolutionary processes such as natural selection and genetic drift act on genetic variation, resulting in certain characteristics becoming more or less common within a population over successive generations. [3]
Gross primary production (GPP) is the amount of chemical energy, typically expressed as carbon biomass, that primary producers create in a given length of time.Some fraction of this fixed energy is used by primary producers for cellular respiration and maintenance of existing tissues (i.e., "growth respiration" and "maintenance respiration").
Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma. [1][2][3][4][5] It is denoted by the abbreviation . [2][4] This is used to measure the removal of ...