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Further dilution: Carboplatin Injection can be further diluted to concentrations as low as 0.5 mg/mL with 5% Dextrose in Water (D5W) or 0.9% Sodium Chloride Injection, USP.
PARAPLATIN aqueous solution can be further diluted to concentrations as low as 0.5 mg/mL with 5% Dextrose in Water (D5W) or 0.9% Sodium Chloride Injection, USP. When prepared as directed,...
24 hours at 22 to 25°C.234 Formation of cisplatin in solutions of carboplatin 1 mg/mL in sodium chloride 0.9% at 25°C with exposure to fluorescent light. Compatibility.
Detailed Carboplatin dosage information for adults. Includes dosages for Ovarian Cancer; plus renal, liver and dialysis adjustments.
When prepared as directed, carboplatin injection is stable for 8 hours at room temperature (25°C). Since no antibacterial preservative is contained in the formulation, it is recommended that carboplatin injection be discarded 8 hours after dilution.
Medscape - Advanced ovarian carcinoma dosing for Paraplatin (carboplatin), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and...
Further dilution to a concentration as low as 0.5 mg/mL is stable at room temperature (25°C) for 8 hours in NS or D5W. Stability has also been demonstrated for dilutions in D5W in PVC bags at room temperature for 9 days (Benaji 1994); however, the manufacturer recommends use within 8 hours due to lack of preservative.
DBL Carboplatin Injection is a ready to use solution containing 10 milligrams/mL carboplatin in Water for Injections. The injections may be further diluted in 5% glucose intravenous infusion.
Reconstitute vial containing 50, 150, or 450 mg of carboplatin powder for injection with 5, 15, or 45 mL, respectively, of sterile water for injection, 5% dextrose injection, or 0.9% sodium chloride injection to provide a solution containing 10 mg/mL.
This short review focuses on the reason for the unusual stability of carboplatin in its aqueous ready-to-use infusion solution, describes the reactions of the drug with biologically common nucleophiles and summarizes the activation chemistry that make the drug more reactive toward substances present in the biological system.