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The brain is a highly energy-consuming and has little capacity to store glucose as glycogen and so depends greatly on mitochondria. Mitochondrial dysfunction has been linked to the dampened neuroplasticity observed in depressed brains. [160]
Central nervous system (CNS) depression is a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness, possibly leading to coma or death. It is the result of inhibited or suppressed brain activity .
[12] [13] [14] One interpretation is that depression manifests due to an imbalance of neurotransmitters in the brain, resulting in feelings of worthlessness and despair. Magnetic resonance imaging shows that the brains of people diagnosed with depression may have a hippocampus up to 10% smaller than those who do not exhibit signs of depression.
Editor’s note: Season 8 of the podcast Chasing Life with Dr. Sanjay Gupta gets back to basics with an in-depth examination of the brain in different states. Each episode will focus on one of ...
Depression can have multiple, sometimes overlapping, origins. Depression can be a symptom of some mood disorders, some of which are also commonly called depression, such as major depressive disorder, bipolar disorder and dysthymia. [7] Additionally, depression can be a normal temporary reaction to life events, such as the loss of a loved one.
The brains have been donated to a lab at Johns Hopkins University in Baltimore. One-third of the brains studied were from people who had been diagnosed with post-traumatic stress disorder.
Depressed children may often display an irritable rather than a depressed mood; [20] most lose interest in school and show a steep decline in academic performance. [30] Diagnosis may be delayed or missed when symptoms are interpreted as "normal moodiness". [26] Elderly people may not present with classical depressive symptoms. [31]
An altered level of consciousness is any measure of arousal other than normal. Level of consciousness (LOC) is a measurement of a person's arousability and responsiveness to stimuli from the environment. [1] A mildly depressed level of consciousness or alertness may be classed as lethargy; someone in this state can be aroused with little ...
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