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The Lives of a Cell: Notes of a Biology Watcher (1974) is collection of 29 essays written by Lewis Thomas for The New England Journal of Medicine between 1971 and 1973. . Throughout his essays, Thomas touches on subjects as various as biology, anthropology, medicine, music (showing a particular affinity for Bach), etymology, mass communication, and com
The Breakthrough is written for the lay reader and includes sections on immunology that have been written for a general audience. It examines the development of cancer immunotherapy, starting with William Coley's work with toxins in the 1890s, moving on to the long hiatus of immunotherapy, and concluding with victory for the believers in the form of regulatory approval of CTLA-4, PD-1, and PD ...
The Annual Review of Cancer Biology is a peer-reviewed academic journal that publishes review articles about oncology. It published its first volume in 2017, making it the 47th journal published by the nonprofit Annual Reviews. Founded by Tyler Jacks and Charles L. Sawyers, it is currently edited by Laura Attardi and Scott A. Armstrong. [3]
Ashford and Porter used electron microscopy to observe mitochondrial fragments in liver lysosomes by 1962, [2] and a 1977 report suggested that "mitochondria develop functional alterations which would activate autophagy." [3] The term "mitophagy" was coined J.J. Lemasters et al. in 2005, [4] though earlier uses dating back to at least 1998 can ...
The mitochondrial unfolded protein response (UPR mt) is a cellular stress response related to the mitochondria. The UPR mt results from unfolded or misfolded proteins in mitochondria beyond the capacity of chaperone proteins to handle them. [1] The UPR mt can occur either in the mitochondrial matrix or in the mitochondrial inner membrane. [1]
Mutually, post-translational alterations of mitochondrial apparatus and the development of transmembrane contact sites among mitochondria and other structures, which both have the potential to link signals from diverse routes that affect mitochondrial membrane dynamics substantially, [36] Mitochondria are wrapped by two membranes: an inner ...
Power, Sex, Suicide: Mitochondria and the Meaning of Life is a 2005 popular science book by Nick Lane of University College London, which argues that mitochondria are central to questions of the evolution of multicellularity, the evolution of sexual reproduction, and to the process of senescence.
The amount of mitochondria per cell also varies by cell type, with some examples being: Erythrocytes: 0 mitochondria per cell. [1] Lymphocytes: 3 mitochondria per cell. [7] Egg cell: Mature metaphase II egg cells can contain 100,000 mitochondria, and 50,000–1,500,000 copies of the mitochondrial genome (corresponding to up to 90% of the egg ...