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Gemfibrozil, sold under the brand name Lopid among others, is a medication used to treat abnormal blood lipid levels. [3] It is generally less preferred than statins . [ 3 ] [ 4 ] Use is recommended together with dietary changes and exercise. [ 3 ]
Fibrates are used in accessory therapy in many forms of hypercholesterolemia, but the combination of some fibrates (e.g., gemfibrozil) with statins is contraindicated due to an increased risk of rhabdomyolysis. [2]
However, not all fibre supplements seem to provide the same defensive effect. A study of 1429 men and women over six months showed that a high-fibre cereal supplement had no protective effect on recurring colorectal adenomas. In addition, no significant improvement in the proportion or features of existing colorectal adenomas was observed.
An estimated 69 percent of adults ages 40 to 79 in the United States take at least one prescription drug, while 22.4 percent take at least five. Before adding any supplement to your routine, be ...
However, the risk was over 10-fold greater if cerivastatin was used, or if the standard statins (atorvastatin, fluvastatin, lovastatin, pravastatin, or simvastatin) were combined with a fibrate (fenofibrate or gemfibrozil) treatment. Cerivastatin was withdrawn by its manufacturer in 2001.
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PPARα (alpha) is the main target of fibrate drugs, a class of amphipathic carboxylic acids (clofibrate, gemfibrozil, ciprofibrate, bezafibrate, and fenofibrate). They were originally indicated for dyslipidemia of cholesterol and more recently for disorders characterized by high triglycerides.