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In 2010, the structure of the human adenovirus was solved at the atomic level, making it the largest high-resolution model ever. The virus is composed of around 1 million amino acid residues and weighs around 150 MDa. [15] [16]
The example used for the following description is Human adenovirus E, a mastadenovirus with a 36 Kbp genome containing 38 protein-coding genes. [2] While the precise number and identity of genes varies among adenoviruses, the basic principles of genome organization and the functions of most of the genes described in this article are shared ...
Adenovirus early region 1A (E1A) is a gene expressed during adenovirus replication to produce a variety of E1A proteins. [1] It is expressed during the early phase of the viral life span. E1A encodes two major proteins in Ad5, translated after alternative splicing of the viral DNA transcript, that are able to cause a variety of different ...
The capsomere is a subunit of the capsid, an outer covering of protein that protects the genetic material of a virus.Capsomeres self-assemble to form the capsid. [1]In this diagram of an Adenovirus, the capsid molecules are clearly visible.
Usually, especially in the presence of adenovirus, the longer intron is preferred, so the 2.3-kb-long mRNA represents the so-called "major splice". In this form the first AUG codon, from which the synthesis of VP1 protein starts, is cut out, resulting in a reduced overall level of VP1 protein synthesis. The first AUG codon that remains in the ...
Human adenovirus 41 (HAdV-F41), is an enteric Adenovirus, a nonenveloped virus with an icosahedral nucleocapsid containing a double-stranded DNA genome. [ 1 ] It can particularly target the gastrointestinal tract to cause gastroenteritis , with symptoms similar to rotavirus gastroenteritis and norovirus . [ 2 ]
In molecular biology, the hexon protein is a major coat protein found in adenoviruses.Hexon coat proteins are synthesised during late infection and form homo-trimers. The 240 copies of the hexon trimer that are produced are organised so that 12 lie on each of the 20 facets.
The VA (viral associated) RNA is a type of non-coding RNA found in adenovirus. [1] [2] It plays a role in regulating translation. [3] There are two copies of this RNA called VAI or VA RNAI and VAII or VA RNAII. These two VA RNA genes are distinct genes in the adenovirus genome. VA RNAI is the major species with VA RNAII expressed at a lower level.