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Something in the Dirt is a 2022 American science fiction comedy horror film directed by and starring Justin Benson and Aaron Moorhead. Written by Benson, it is the fifth feature film by the directing duo. The film had its world premiere online at the 2022 Sundance Film Festival in January 2022. [1]
A man with pellagra, which is caused by a chronic lack of vitamin B 3 in the diet. Severe deficiency of niacin in the diet causes the disease pellagra, characterized by diarrhea, sun-sensitive dermatitis involving hyperpigmentation and thickening of the skin (see image), inflammation of the mouth and tongue, delirium, dementia, and if left untreated, death. [7]
Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B 3). [2] Symptoms include inflamed skin, diarrhea, dementia, and sores in the mouth. [1] Areas of the skin exposed to friction and radiation are typically affected first. [1] Over time affected skin may become darker, stiffen, peel, or bleed. [1] [3]
It was a combination of the lipid-modifying drug/vitamin niacin in extended release form and the statin drug lovastatin (trade name Mevacor). The combination preparation was developed by Kos Pharmaceuticals, Inc., which was acquired by Abbott Laboratories in 2006, subsequently transferred to AbbVie Inc. when that company was spun off from ...
Niacin is available as a prescription product, either immediate release (500 mg tablets; prescribed up to 3,000 mg/day) or extended release (500 and 1,000 mg tablets; prescribed up to 2,000 mg/day). In the US, niacin is also available as a dietary supplement at 500 to 1,000 mg/tablet. Niacin has sometimes been used in combination with other ...
Example of a label showing the amount of niacin (Vitamin B3), and specifying to be niacinamide in the ingredient section.. The United States adopted in 1942 the terms niacin to nicotinic acid and niacinamide to nicotinamide to avoid references to nicotine, [12] [13] the terms were incorporated into the United States Adopted Name [14] that was created later in 1961.
Newborn infants are a special case. Plasma vitamin K is low at birth, even if the mother is supplemented during pregnancy, because the vitamin is not transported across the placenta. Vitamin K deficiency bleeding (VKDB) due to physiologically low vitamin K plasma concentrations is a serious risk for premature and term newborn and young infants.
Single-dose administration of up to 500 mg was shown safe in men in a study at Keio University. [10] One 2021 clinical trial found that NMN improved muscular insulin sensitivity in prediabetic women, [ 11 ] while another found that it improved aerobic capacity in amateur runners. [ 12 ]