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Interleukins (ILs) are a group of cytokines ... Not only does IL-17 play a key role in inflammation of many autoimmune diseases, such as RA, allergies, asthma ...
Some inflammatory cytokines have additional roles such as acting as growth factors. [5] Pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α also trigger pathological pain. [1] While IL-1β is released by monocytes and macrophages, it is also present in nociceptive DRG neurons. IL-6 plays a role in neuronal reaction to an injury.
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene. [5] In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine.
Inflammatory responses in the absence of infection (such as ischemia) are only dependent on IL-1α signaling via the Interleukin-1 receptor (IL-1R), rather than TLRs signaling. IL-1α also stimulates transcription and secretion of IL-1β from monocytes , so the initiator of immune responses is likely IL-1α precursor by induction of neutrophil ...
Interleukin-2 (IL-2) is an interleukin, which is a type of cytokine signaling molecule forming part of the immune system.It is a 15.5–16 kDa protein [5] that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity.
Interleukin 17 family (IL17 family) is a family of pro-inflammatory cystine knot cytokines. [2] They are produced by a group of T helper cell known as T helper 17 cell in response to their stimulation with IL-23.
3586 16153 Ensembl ENSG00000136634 ENSMUSG00000016529 UniProt P22301 P18893 RefSeq (mRNA) NM_000572 NM_010548 RefSeq (protein) NP_000563 NP_034678 Location (UCSC) Chr 1: 206.77 – 206.77 Mb Chr 1: 130.95 – 130.95 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti- inflammatory cytokine ...
Interleukin-8 is a key mediator associated with inflammation where it plays a key role in neutrophil recruitment and neutrophil degranulation. [16] As an example, it has been cited as a proinflammatory mediator in gingivitis [ 17 ] and psoriasis .