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Spironolactone can cause breast pain and breast enlargement in women. [128] [129] This is "probably because of estrogenic effects on target tissue." [111] At low doses, breast tenderness has been reported in only 5% of women, but at high doses, it has been reported in up to 40% of women.
The onset of action of the antimineralocorticoid effects of spironolactone is relatively slow, with the peak effect sometimes occurring 48 hours or more after the first dose. [ 1 ] [ 24 ] Canrenone is an antagonist of the MR as is spironolactone, [ 25 ] but it is slightly more potent in comparison.
After pregnancy, breast pain can be caused by breastfeeding. [5] Other causes of non-cyclical breast pain include alcoholism with liver damage (likely due to abnormal steroid metabolism), mastitis and medications such as digitalis, methyldopa (an antihypertensive), spironolactone, certain diuretics, oxymetholone (an anabolic steroid), and ...
Plus, hormone therapy can have some other worthwhile benefits. For example, hormone therapy can help prevent osteoporosis. With the drop in estrogen that accompanies menopause, you begin to lose bone.
Certain side effects, like breast enlargement, reduced premenstrual symptoms, and less oily skin/greasy hair, could be beneficial. Side effects often could not be unambiguously attributed to spironolactone due concomitant use of other medications, particularly birth control pills.
The American College of Obstetricians and Gynecologists (ACOG) also says that hormonal changes the week before a period can cause breast pain and tenderness. Birth control or hormone therapy.
Breast tension is a constellation of symptoms involving the breasts including: Breast pain (also called mastalgia) [1] Breast engorgement; It can be a side effect of estrogen-containing drugs used for hormone replacement therapy during menopause. [2]
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