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The long-chain bases, sometimes simply known as sphingoid bases, are the first non-transient products of de novo sphingolipid synthesis in both yeast and mammals. These compounds, specifically known as phytosphingosine and dihydrosphingosine (also known as sphinganine, [4] although this term is less common), are mainly C 18 compounds, with somewhat lower levels of C 20 bases. [5]
Sphingomyelin can be found in eggs or bovine brain. This sphingolipid is synthesized at the endoplasmic reticulum and is enriched at the plasma membrane with a larger concentration on the outside. [11] Other phospholipids. There are many other phospholipids, some of which are glycolipids. The glycolipids include phosphatidyl sugars where the ...
Phospholipids and glycolipids consist of two long, nonpolar (hydrophobic) hydrocarbon chains linked to a hydrophilic head group. The heads of phospholipids are phosphorylated and they consist of either: Glycerol (and hence the name phosphoglycerides given to this group of lipids), or; Sphingosine (e.g. sphingomyelin and ceramide).
Fatty acids are hydrocarbon derivatives; they contain a carboxyl group "head" and a hydrocarbon chain "tail". [4] These fatty acids create larger components, which in turn incorporate noncovalent interactions to form the lipid bilayer. [4] Fatty acid chains are found in two major components of membrane lipids: phospholipids and sphingolipids.
Phospholipids [1] are a class of lipids whose molecule has a hydrophilic "head" containing a phosphate group and two hydrophobic "tails" derived from fatty acids, joined by an alcohol residue (usually a glycerol molecule). Marine phospholipids typically have omega-3 fatty acids EPA and DHA integrated as part of the phospholipid molecule. [2]
The membrane phospholipids incorporate fatty acyl chains of varying length and saturation. Lipids with shorter chains are less stiff and less viscous because they are more susceptible to changes in kinetic energy due to their smaller molecular size and they have less surface area to undergo stabilizing London forces with neighboring hydrophobic ...
Cholesterol interacts preferentially, although not exclusively, with sphingolipids due to their structure and the saturation of the hydrocarbon chains. Although not all of the phospholipids within the raft are fully saturated, the hydrophobic chains of the lipids contained in the rafts are more saturated and tightly packed than the surrounding ...
Phospholipids: Phospholipids are a major component of the lipid bilayer of the cell membrane and are found in many parts of the body. [25] Sphingolipids: Sphingolipids are mostly found in the cell membrane of neural tissue. [18] Glycolipids: The main role of glycolipids is to maintain lipid bilayer stability and facilitate cell recognition. [25]