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Subependymal giant cell astrocytoma (SEGA, SGCA, or SGCT) is a low-grade astrocytic brain tumor (astrocytoma) that arises within the ventricles of the brain. [1] It is most commonly associated with tuberous sclerosis complex (TSC). Although it is a low-grade tumor, its location can potentially obstruct the ventricles and lead to hydrocephalus.
Astrocytoma is a type of brain tumor. Astrocytomas (also astrocytomata) originate from a specific kind of star-shaped glial cell in the cerebrum called an astrocyte . This type of tumor does not usually spread outside the brain and spinal cord and it does not usually affect other organs.
The best way to distinguish it from a subependymal giant cell astrocytoma is the size. [2] Diagnosis. The diagnosis is based on tissue, e.g. a biopsy.
1.4.1 Pilocytic astrocytoma 1.4.2 High-grade astrocytoma with piloid features 1.4.3 Pleomorphic xanthoastrocytoma 1.4.4 Subependymal giant cell astrocytoma 1.4.5 Chordoid glioma 1.4.6 Astroblastoma, MN1-altered 1.5 Glioneuronal and neuronal tumours 1.5.1 Ganglioglioma 1.5.2 Desmoplastic infantile ganglioglioma / desmoplastic infantile astrocytoma
The tau protein is a critical part of the cell skeleton, known as the cytoskeleton, and the deposits of insoluble tau disrupt the structure of brain cells. These plaques and tangles are thought to ...
Ependymomas are composed of cells with regular, round to oval nuclei. There is a variably dense fibrillary background. Tumor cells may form gland-like round or elongated structures that resemble the embryologic ependymal canal, with long, delicate processes extending into the lumen; more frequently present are perivascular pseudorosettes in which tumor cells are arranged around vessels with an ...