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[2] [3] It is analogous to andropause in men and menopause in women, the abrupt or gradual decline in production of sex hormones from the gonads with age. [4] DHEA can be supplemented or taken as a medication in the form of prasterone to replace adrenal androgens later in life if it is desired. [2]
“Ovaries make testosterone,” says Kelly Casperson, ... “Before menopause, the main hormone is estrogen, and after menopause, androgens like testosterone become more prevalent,” Stanhiser says.
Androstenedione is the common precursor of the androgen and estrogen sex hormones. [7] ... the adrenal glands and ovaries each produce about half ... After menopause, ...
Dehydroepiandrosterone (DHEA) is a steroid hormone produced in the adrenal cortex from cholesterol. [5] It is the primary precursor of both the androgen and estrogen sex hormones. DHEA is also called dehydroisoandrosterone or dehydroandrosterone. Androstenedione (A4) is an androgenic steroid produced by the testes, adrenal cortex, and ovaries.
These precursors are not further converted in the adrenal cortex if the cells lack 17β-Hydroxysteroid dehydrogenase. Instead, they are released into the blood stream and taken up in the testicles and ovaries to produce testosterone and the estrogens respectively. ACTH partially regulates adrenal androgen secretion, [4] also CRH. [5] [6]
Hyperandrogenism is a medical condition characterized by high levels of androgens.It is more common in women than men. [4] Symptoms of hyperandrogenism may include acne, seborrhea, hair loss on the scalp, increased body or facial hair, and infrequent or absent menstruation.