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Agglutination is a reaction in which particles (as red blood cells or bacteria) suspended in a liquid collect into clumps usually as a response to a specific antibody. Agglutination(clumping) of red blood cells. This occurs in biology in two main examples: The clumping of cells such as bacteria or red blood cells in the presence of an antibody ...
The antigens and antibodies combine by a process called agglutination. It is the fundamental reaction in the body by which the body is protected from complex foreign molecules, such as pathogens and their chemical toxins. In the blood, the antigens are specifically and with high affinity bound by antibodies to form an antigen-antibody complex.
Red cell agglutination in a patient with cold agglutinin disease. In hematology, red cell agglutination or autoagglutination is a phenomenon in which red blood cells clump together, forming aggregates. It is caused by the surface of the red cells being coated with antibodies.
As a result, the blood of a host applied to a diagnostic kit causes the aggregation of the pathogenic particles due to the antigen-agglutinin interaction. Conversely, agglutination can also be used to identify new bacteria or cells with a specific antigen by exposing them to serum containing known agglutinins. [3]
Agglutinogen is an antigen [1] that causes the formation of agglutinins in the body and leads to agglutination, such as hemagglutination, which involves red blood cells (RBCs). The kind of agglutinogens present on the red blood cells helps determine the blood type of a person. [2]
Symptoms of AIHA may be due to the underlying anemia; including shortness of breath or dyspnea, fatigue, headache, muscle weakness and pallor. [10] In cold agglutinin disease (cold antibody type), agglutination and impaired passage of red blood cells through capillaries in the extremities causes acrocyanosis and Raynaud phenomenon with a rare complication of gangrene [4]
This is a nonspecific indicator of the presence of disease. [1] Rouleaux formation on patient vaginal swab wet smear. Conditions that cause rouleaux formation include infections, multiple myeloma, Waldenström's macroglobulinemia, inflammatory and connective tissue disorders, and cancers.
It does not identify the Rh(D) antigen (Rh blood type). The bedside card method of blood grouping relies on visual agglutination to determine an individual's blood group. The card contains dried blood group antibody reagents fixed onto its surface. A drop of the individual's blood is placed on each blood group area on the card.