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Depression is a mental state of low mood and aversion to activity. [3] It affects about 3.5% of the global population , or about 280 million people worldwide, as of 2020. [ 4 ] Depression affects a person's thoughts , behavior , feelings , and sense of well-being . [ 5 ]
Anhedonia is a diverse array of deficits in hedonic function, including reduced motivation or ability to experience pleasure. [1] While earlier definitions emphasized the inability to experience pleasure, anhedonia is currently used by researchers to refer to reduced motivation, reduced anticipatory pleasure (wanting), reduced consummatory pleasure (liking), and deficits in reinforcement learning.
This article needs to be updated. The reason given is: Many outdated sources and information (older than five years). Please help update this article to reflect recent events or newly available information. (July 2024) Medical condition Major depressive disorder Other names Clinical depression, major depression, unipolar depression, unipolar disorder, recurrent depression Sorrowing Old Man (At ...
A general lack of energy, fatigue, and tiredness that cannot be otherwise explained is also a symptom of a major depressive episode. [3] A person may feel tired without engaging in any physical activity, which may cause day-to-day tasks, such as showering, to become unmanageable. [10]
In addition to evidence suggesting that inflammation is not sufficient for the development of major depression, evidence for a lack of complete overlap also comes from findings that depression often occurs without existing immune challenges, with social adversity appearing to cause depression without the requirement of underlying inflammation.
The biology of depression is the attempt to identify a biochemical origin of depression, as opposed to theories that emphasize psychological or situational causes. Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD). [1]
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