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L-arginine is recognized as safe (GRAS-status) at intakes of up to 20 grams per day. [51] L-arginine is found in many foods, such as fish, poultry, and dairy products, and is used as a dietary supplement. [52] It may interact with various prescription drugs and herbal supplements. [52]
Arginine/lysine, sold under the brand name Lysakare, is a fixed-dose combination medication used to protect the kidneys from radiation damage during cancer treatment with a radioactive medicine called lutetium (177 Lu) oxodotreotide. [2] It contains L-arginine hydrochloride and L-lysine hydrochloride. [2]
In enzymology, a tyrosine—arginine ligase (EC 6.3.2.24) is an enzyme that catalyzes the chemical reaction. ATP + L-tyrosine + L-arginine AMP + diphosphate + L-tyrosyl-L-arginine. The 3 substrates of this enzyme are ATP, L-tyrosine, and L-arginine, whereas its 3 products are AMP, diphosphate, and L-tyrosyl-L-arginine.
A number of injectable arginine vasopressins are in clinical use in the United States and the European Union. Pitressin among others, is a medication most commonly used in the treatment of frequent urination , increased thirst , and dehydration such as that resulting from diabetes insipidus , which causes increased and diluted urine.
[1] [2] Chemically, it is a methyl derivative of the amino acid arginine. It is used as a biochemical tool in the study of physiological role of nitric oxide . The inhibiting effect of N -methylarginine on vasodilation is lower in hypertensive patients than in normal subjects, indicating endothelial dysfunction . [ 3 ]
Argininemia is an autosomal recessive urea cycle disorder where a deficiency of the enzyme arginase causes a buildup of arginine and ammonia in the blood.Ammonia, which is formed when proteins are broken down in the body, is toxic if levels become too high; the nervous system is especially sensitive to the effects of excess ammonia.